4 credits 60 theoretical hours
Objectives
Address the role of metals, the main metalloproteins and metalloenzymes in biological systems. Show the main metal complexes applied in medicine, both in therapy and diagnosis, their biological targets, mechanisms of action and recent advances.
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Introduction to the study of metalloproteins and metal ion homeostasis; as well as correlated diseases and toxicity of different metal ions. Metals in medicine: study of metal complexes for the treatment of diseases and metal complexes used for clinical diagnosis.
Program Content
1. Introduction to the study of metal ions in cellular metabolism
1.1. Structure of metalloproteins, prosthetic groups and enzymatic cofactors
1.2. Importance of the main metalloproteins in cellular metabolism
1.3. Inborn errors of metabolism associated with metalloproteins
2. Homeostasis of essential and non-essential metal ions
2.1. Metabolism of iron, copper and other essential metal ions
2.2. Fenton reactions and the generation of free radicals
2.3. Toxicity of cadmium, chromiumVI and other non-essential metal ions
3. Platinum Complexes in Cancer Therapy
3.1. Cisplatin mechanism of action
3.2. Resistance mechanisms associated with cisplatin
3.3. 2nd and 3rd generation complexes
4. New strategies for obtaining antitumor metal complexes
4.1. Non-Traditional Platinum Complexes
4.2. Non-Platinum-Based Complexes
4.3. Non-classical metal complexes: Au, Gd, Ga, among others.
4.4. Obtaining prodrugs: complexes of CoIII, PtIV, RuII, metalloporphyrins, etc.
5. Metal complexes in the treatment of other diseases
5.1. Ferroquine and analogues in the treatment of malaria
5.2. Antimonials in the treatment of Leishmaniasis
5.3. Complexes of gold (arthritis), vanadium (diabetes), ruthenium (Alzheimer’s), etc.
6. Metal complexes as diagnostic agents
6.1. Complexes as imaging agents
6.2. Theranostic complexes
METHODOLOGY:
Expository classes, with various teaching resources (blackboard/chalk, data show, multimedia and computers). Students will be assessed with individual seminars and individual or group work.
BASIC BIBLIOGRAPHY:
1) Nelson, Devis. Lehninger’s Principles of Biochemistry. 6th ed. Porto Alegre: Artmed, 2014.
2) Kraatz, H.; Metzler-Nolte, N. Concepts and Models in Bioinorganic Chemistry. John Wiley & Sons, 2006.
2) Roat-Malone, Bioinorganic Chemistry: a short course. John Wiley & Sons, 2002.
3) Miessler, G. L., Tarr, D. A. “Inorganic Chemistry”; 5th Ed. New Jersey, Pearson, 2014.
4) Articles from specialized periodicals with international circulation.
