{"id":7971,"date":"2025-04-03T10:38:37","date_gmt":"2025-04-03T13:38:37","guid":{"rendered":"https:\/\/cursos.ufrrj.br\/posgraduacao\/ppgq\/?page_id=7971"},"modified":"2025-04-03T10:38:37","modified_gmt":"2025-04-03T13:38:37","slug":"ic-1332a-special-topics-classic-discoveries-in-biochemistry-and-molecular-biology","status":"publish","type":"page","link":"https:\/\/cursos.ufrrj.br\/posgraduacao\/ppgq\/en\/ic-1332a-special-topics-classic-discoveries-in-biochemistry-and-molecular-biology\/","title":{"rendered":"IC-1332a \u2013 Special Topics: Classic Discoveries in Biochemistry and Molecular Biology"},"content":{"rendered":"

2 credits 30 theoretical hours<\/strong><\/p>\n

OBJECTIVE OF THE DISCIPLINE<\/strong>: To enable a broad scientific view of the most varied
\nBiochemistry topics from the researchers’ point of view and not from the topics studied.<\/p>\n

SUMMARY<\/strong>: Bibliographic review of the main discoveries in the area of \u200b\u200bBiochemistry and Biology
\nMolecular<\/p>\n

ANALYTICAL PROGRAM<\/strong>
\n1. Nucleic acids and genetic information
\n1.1. Structure of DNA \u2013 Rosalind Franklin
\n1.2. The discovery of introns \u2013 Richard J. Roberts and Philip A. Sharp
\n1.3. Fragments of Okasaki \u2013 Reiji Okasaki
\n2.Amino acids
\n2.1. Discovery of the 20th amino acid (threonine) \u2013 Willian C. Rose
\n2.2. Discovery of the 21st amino acid (selenocysteine) \u2013 A. Bock
\n2.3. Discovery of the 22nd amino acid (pyrrolysine) \u2013 Joseph Krzycki, John Atkins, Ray Gesteland
\n(2002)<\/p>\n

3. Peptides and Proteins
\n3.1. Discovery of insulin \u2013 Frederick Banting and Charles Best
\n3.2. Protein sequencing \u2013 Frederick Sanger
\n3.3. Structure and Function of Hemoglobin \u2013 Max Perutz
\n4. Enzymes
\n4.1. Enzymatic action \u2013 J. B. S. Haldane
\n4.2. DNA polymerase \u2013 Arthur Kornberg
\n4.3. ATP synthase \u2013 John E. Walker
\n4.4. Polysaccharide (glycogen) phosphorylase \u2013 Carl and Gerty Cori
\n5. Metabolism
\n5.1. Study of metabolism \u2013 Otto Warburg
\n5.2. The Cori cycle \u2013 Carl and Gerty Cori
\n5.3. The tricarboxylic acid cycle \u2013 Hans Krebs
\n5.4. Chemiosmotic Theory \u2013 Peter Mitchell
\n5.5. Cellular fermentation \u2013 Eduard Buchner
\n5.6. The Calvin cycle \u2013 Melvin Calvin
\n5.7. Cholesterol biosynthesis \u2013 Konrad Bloch
\n5.8. The ornithine cycle \u2013 Hans Krebs
\n5.9. Biosynthesis of saccharides \u2013 Luis Leloir<\/p>\n

Bibliography
\nMcCoy, R.H.; Meyer, C.E.; Rose, W. C. (1935). J. Biol. Chem. 112, 283-302.
\nPerutz, M.F.; Rossman, M. G., Cullis, A. F.; Muirhead, H.; Will, G.; North, A.C.T. (1960). Nature, 185, 416-422.
\nBriggs, G. E.; Haldane, J.B.S. (1925) Biochem. J. 19, 339.
\nWarburg, O. (1956). Science, 123, 309-314.
\nCori, G. T., Colowick, S. P., Cori, C. F. (1939). J. Biol Chem., 127, 771-782.
\nKrebs, H. A., Johnson, W. A. \u200b\u200b(1937). Enzymologia, 4, 148-156.
\nMitchell, P. (1961). Nature, 191, 144-148.
\nBanting, F. G., Best, C. H. (1922) J. Lab. Clin. Med. 7, 251-266.
\nFranklin, R.E., Gosling, R.G. (1953). Nature, 171, 740-741.
\nKornberg, A. (1969). Science, 163, 1410-1418.
\nChow, L. T., Gelinas, R. E., Roberts, R. J. (1977). Cell, 12, 1-8.
\nBerget, D. M., Moore, C., Sharp, P. A. (1977). Proc. Natl. Academic. Sci., 74, 3171\u20133175.
\nOkazak,i R.; Okazaki, T.; Sakabe, K.; Sugimoto, K. (1967). Jpn J Med Sci Biol., 20(3), 255-260.
\nAtkins, J. F.; Gesteland, R. (2002). Science, 296 (5572), 1409\u20131410.
\nKrzycki, J. (2005). Curr. Opinion. Microbiol., 8(6), 706\u2013712.
\nZinoni, F.; Birkmann, A.; Stadtman, T. C; B\u00f6ck, A. (1986). PNAS, 83, 4650-4654.
\nCalvin, M. (1956). Bull. Soc. Chim. Biol. 38 (11),. 1233\u20131244.
\nBloch, K., Rittenberg, D. (1942) J. Biol. Chem. 145, 625-636<\/p>\n","protected":false},"excerpt":{"rendered":"

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