{"id":2579,"date":"2017-11-22T09:25:17","date_gmt":"2017-11-22T12:25:17","guid":{"rendered":"http:\/\/cursos.ufrrj.br\/posgraduacao\/ppgq\/?page_id=2579"},"modified":"2017-11-22T10:33:47","modified_gmt":"2017-11-22T13:33:47","slug":"ic-1304","status":"publish","type":"page","link":"https:\/\/cursos.ufrrj.br\/posgraduacao\/ppgq\/atividades-disciplinares\/ic-1304\/","title":{"rendered":"IC-1304 \u2013 Qu\u00edmica Bioorg\u00e2nica"},"content":{"rendered":"

4 Cr\u00e9ditos \u2013 60 horas te\u00f3ricas<\/strong><\/p>\n

 <\/p>\n

EMENTA<\/strong>:<\/p>\n

1. Metabolismo Vegetal<\/p>\n

2. Metabolismo prim\u00e1rio e especial<\/p>\n

3. Mecanismos de constru\u00e7\u00e3o dos metab\u00f3litos especiais<\/p>\n

4. Metabolismo Especial. Vis\u00e3o geral do metabolismo vegetal: metabolismo prim\u00e1rio e especial<\/p>\n

 <\/p>\n

CONTE\u00daDO PROGRAM\u00c1TICO<\/strong>:<\/p>\n

1. Metabolismo vegetal<\/em><\/p>\n

Metab\u00f3litos especiais (secund\u00e1rios). Papel fisiol\u00f3gico dos metab\u00f3litos especiais. Intera\u00e7\u00e3o plantasmicroorganismos.<\/p>\n

Toxinas antimicrobianas: pr\u00e9 e p\u00f3s- infeccional. O custo da defesa qu\u00edmica.<\/p>\n

Crescimento versus desenvolvimento vegetal (plantas de crescimento dominante e plantas de<\/p>\n

diferencia\u00e7\u00e3o dominante). Vis\u00e3o geral do metabolismo prim\u00e1rio e do metabolismo especial.<\/p>\n

2. Processos Metab\u00f3licos Prim\u00e1rios<\/em><\/p>\n

C\u00e9lulas eucari\u00f3ticas e procari\u00f3ticas. Locais de ac\u00famulo de compostos especiais. Metabolismo prim\u00e1rio:<\/p>\n

Prote\u00ednas. Enzimas. Coenzimas<\/p>\n

Metabolismo prim\u00e1rio: vias de produ\u00e7\u00e3o de acetil-CoA, ATP e poder redutor.<\/p>\n

Glic\u00f3lise. Ciclo de Kreks.<\/p>\n

Cadeia de transporte de el\u00e9trons. Complexos enzim\u00e1ticos e transportadores m\u00f3veis de el\u00e9trons.<\/p>\n

Fosforila\u00e7\u00e3o oxidativa mitocondrial<\/p>\n

Via das pentoses-fosfato. Gliconeog\u00eanese.<\/p>\n

Degrada\u00e7\u00e3o de \u00e1cidos gr\u00e1xos. Ciclo do Glioxilato.<\/p>\n

Fotoss\u00edntese. Capta\u00e7\u00e3o e convers\u00e3o da energia luminosa em energia qu\u00edmica. Fotofosforila\u00e7\u00e3o oxidativa<\/p>\n

Ciclo de Calvin-Benson. Vias C2 e C4.<\/p>\n

Manipula\u00e7\u00e3o g\u00eanica para a produ\u00e7\u00e3o de metab\u00f3litos especiais<\/p>\n

Rela\u00e7\u00e3o metabolismo prim\u00e1rio e especial.<\/p>\n

3. Mecanismos de constru\u00e7\u00e3o dos metab\u00f3litos especiais<\/em><\/p>\n

Blocos de constru\u00e7\u00e3o que formam a base dos metab\u00f3litos especiais: C2; C5; C6C3; C6C2N; Indol-C2N;<\/p>\n

C4N, C5N;<\/p>\n

Rea\u00e7\u00f5es de alquila\u00e7\u00e3o: Substitui\u00e7\u00e3o nucleof\u00edlica (Forma\u00e7\u00e3o de S-adenosilmetionina\/SAM; O e Nalquila\u00e7\u00e3ousando SAM; C-alquila\u00e7\u00e3o usando SAM; O-alquila\u00e7\u00e3o usando dimetilalildifosfato\/DMAPP)<\/p>\n

Rea\u00e7\u00f5es de alquila\u00e7\u00e3o: Adi\u00e7\u00e3o eletrof\u00edlica (Adi\u00e7\u00f5es inter e intra molecular; Gera\u00e7\u00e3o de carbocation;<\/p>\n

Descarga de carbocation). Rearranjos Wagner-Meerwein.<\/p>\n

Rea\u00e7\u00f5es Aldol e Claisen.<\/p>\n

Forma\u00e7\u00e3o de Base Schiff (Forma\u00e7\u00e3o de base Schiff; Hidr\u00f3lise de base Schiff)<\/p>\n

Rea\u00e7\u00e3o Mannich<\/p>\n

Transamina\u00e7\u00e3o<\/p>\n

Rea\u00e7\u00f5es de Descarboxila\u00e7\u00e3o (Amino\u00e1cidos; \u03b2-cetoacidos; \u03b1-ceto\u00e1cidos)<\/p>\n

Rea\u00e7\u00f5es de Oxida\u00e7\u00e3o e Redu\u00e7\u00e3o: Desidrogenases (NAD+ e NADP+; FAD e FMN); Oxidases;<\/p>\n

Oxigenases (mono e dioxigenases); Amino Oxidases (mono e diamino oxidases; Oxida\u00e7\u00f5es Bayer-<\/p>\n

Villiger<\/p>\n

Acoplamento oxidativo fen\u00f3lico. Rea\u00e7\u00f5es de glicosila\u00e7\u00e3o: O-glicosila\u00e7\u00e3o; Hidr\u00f3lise de O-glicos\u00eddeos;<\/p>\n

C-Glicosila\u00e7\u00e3o<\/p>\n

4. Metabolismo Especial.<\/em><\/p>\n

Metabolismo dos Isopren\u00f3ides (terpen\u00f3ides): Convers\u00e3o do \u00e1cido meval\u00f4nico em isopentenilpirofosfato.<\/p>\n

Principais classes de isopren\u00f3ides: Monoterpenos; Sesquiterpenos; Diterpenos, Tetraterpenos;<\/p>\n

Triterpenos: ester\u00f3is e fitoester\u00f3is<\/p>\n

Via do shiquimato-arogenato.<\/p>\n

Metabolismo geral dos fenilpropan\u00f3ides. Compostos fen\u00f3licos. Flavon\u00f3ides, Ligninas, Lignanas,<\/p>\n

Taninos.<\/p>\n

Metabolismo de Nitrog\u00eanio em plantas.<\/p>\n

S\u00edntese de amino\u00e1cidos arom\u00e1ticos: fenilalanina; tirosina e triptofano<\/p>\n

Compostos contendo nitrog\u00eanio: Amino\u00e1cidos n\u00e3o prot\u00e9icos, Aminas<\/p>\n

Glicos\u00eddeos Cianog\u00eanicos. Glicosinolatos.<\/p>\n

Alcal\u00f3ides<\/p>\n

Vis\u00e3o geral do metabolismo vegetal: metabolismo prim\u00e1rio e especial<\/p>\n

 <\/p>\n

BIBLIOGRAFIA<\/strong>:<\/p>\n

Barreiro, E.J.; Fraga, C.A.M. Qu\u00edmica Medicinal. As bases moleculares da a\u00e7\u00e3o dos f\u00e1rmacos. Artmed.<\/p>\n

2002. 243p<\/p>\n

Buchanan, B.B.; Gruissem, W.; Jones, R.L. Biochemistry & Molecular Biology of Plants. A.S.P.P.<\/p>\n

2000.1366 p.<\/p>\n

Dey, P.M.; Harborne, J.B. Plant Biochemistry. Acad. Press. 1997. 554 p.<\/p>\n

Nelson, D. e Cox, M. Princ\u00edpios de Bioqu\u00edmica Sarvier. 2002<\/p>\n

Stryer, L. Bioqu\u00edmica. Guanabara Koogan. 4a. ed. 2003.<\/p>\n

Voet, B., Voet, J.G. Pratt, C. Fundamentos de Bioqu\u00edmica. ArtMed. 2000<\/p>\n","protected":false},"excerpt":{"rendered":"

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