{"id":373,"date":"2018-04-17T13:00:02","date_gmt":"2018-04-17T13:00:02","guid":{"rendered":"http:\/\/cursos.ufrrj.br\/posgraduacao\/pmpgcf\/?page_id=373"},"modified":"2019-11-28T11:11:03","modified_gmt":"2019-11-28T14:11:03","slug":"laboratorio-de-farmacologia-da-inflamacao-e-nocicepcao","status":"publish","type":"page","link":"https:\/\/cursos.ufrrj.br\/posgraduacao\/pmpgcf\/laboratorio-de-farmacologia-da-inflamacao-e-nocicepcao\/","title":{"rendered":"Laborat\u00f3rio de farmacologia da inflama\u00e7\u00e3o e da nocicep\u00e7\u00e3o"},"content":{"rendered":"

Descri\u00e7\u00e3o do Laborat\u00f3rio de Farmacologia da inflama\u00e7\u00e3o e nocicep\u00e7\u00e3o<\/strong><\/p>\n

 <\/p>\n

O Laborat\u00f3rio de Farmacologia da inflama\u00e7\u00e3o e nocicep\u00e7\u00e3o \u00e9 coordenado pelos Dr.<\/strong> Bruno Guimar\u00e3es Marinho<\/strong> <\/a>(Prof. Associado II),\u00a0 Dr.<\/strong> David do Carmo Malvar<\/strong><\/a> (Prof. Adjunto II)\u00a0 e Dr.<\/strong> Wellington da Silva C\u00f4rtes<\/strong><\/a> (Prof. Associado IV). O laborat\u00f3rio tem por objetivo utilizar m\u00e9todos de investiga\u00e7\u00e3o cient\u00edfica que possam permitir o desenvolvimento de abordagens terap\u00eauticas para minimizar ou prevenir o estabelecimento de condi\u00e7\u00f5es \u00e1lgicas e inflamat\u00f3rias, atrav\u00e9s da busca por alvos farmacol\u00f3gicos e por mol\u00e9culas naturais ou sint\u00e9ticas analg\u00e9sicas e\/ou anti-inflamat\u00f3rias. O laborat\u00f3rio disp\u00f5e de infraestrutura para realiza\u00e7\u00e3o de modelos algesim\u00e9tricos e inflamat\u00f3rios in vivo<\/em> e tamb\u00e9m an\u00e1lises ex vivo<\/em> e in vitro<\/em> atrav\u00e9s de imunoensaios (ELISA e Multiplex), Western blot<\/em>, imunohistoqu\u00edmica e RT-PCR. Dentre as linhas desenvolvidas atualmente est\u00e3o: 1) Desenvolvimento de mol\u00e9culas h\u00edbridas a partir de derivados tetrahidropir\u00e2nicos com potencial anti-inflamat\u00f3rio e analg\u00e9sico; 2)Estudo do potencial analg\u00e9sico e anti-inflamat\u00f3rio de \u00f3leos essenciais e partes a\u00e9reas de plantas das fam\u00edlias Euphorbiaceae, Fabaceae, Myrtaceae, Primulaceae entre outras \u00e9species vegetais de uso medicinal, aliment\u00edcio ou ornamental; 3) Avalia\u00e7\u00e3o do potencial antinociceptivo, anti-inflamat\u00f3rio e anti-artrite do extrato aquoso das folhas de Cecropia hololeuca e suas fra\u00e7\u00f5es; 4) Investiga\u00e7\u00e3o do potencial\u00a0 antinociceptivo, anti-inflamat\u00f3rio e anti-artrite do LQB-118; 5) Avalia\u00e7\u00e3o das atividades farmacol\u00f3gicas de compostos indanodi\u00f4nicos e derivados barbit\u00faricos.<\/p>\n

 <\/p>\n

Integrantes:<\/strong><\/p>\n

Bruno Guimar\u00e3es Marinho (Coordenador)<\/a><\/p>\n

David do Carmo Malvar (Coordenador)<\/a><\/p>\n

Wellington da Silva C\u00f4rtes (Coordenador)<\/a><\/p>\n

Alana Belem Ferreira (Graduanda do Curso de Farm\u00e1cia)<\/p>\n

Amanda da Costa Barbosa L\u00e1zaro (Graduanda do Curso de Medicina Veterin\u00e1ria)<\/p>\n

Amanda da Silva Salgado (Graduanda do Curso de Medicina Veterin\u00e1ria)<\/p>\n

Ana Paula Alves Amaral (Graduanda do Curso de Farm\u00e1cia)<\/p>\n

Andr\u00e9 Romero Henrique da Costa (Mestrando)<\/p>\n

Emanoelly Barbosa Sacramento\u00a0 (Inicia\u00e7\u00e3o cient\u00edfica \u2013 Bolsista PIBIC)<\/p>\n

\u00c9rica Larissa Oliveira Gripp (Inicia\u00e7\u00e3o cient\u00edfica \u2013 Bolsista PIBIC)<\/p>\n

Gabriela Mastrangelo Gon\u00e7alves (Doutoranda)<\/p>\n

Gustavo Nunes de Santana Castro (Doutorando)<\/p>\n

Joyce de MHeydikel Ferreira Braga (Graduanda do Curso de Farm\u00e1cia)attos Oliveira (Doutoranda)<\/p>\n

Leonardo Lopes Rosa\u00a0 (Graduando do Curso de Farm\u00e1cia)<\/p>\n

Lilian Uchoa Carneiro (Doutoranda)<\/p>\n

Lizandra de F\u00e1tima Brand\u00e3o Torquato ( Inicia\u00e7\u00e3o cient\u00edfica \u2013 Bolsista FAPERJ)<\/p>\n

Marcos Oliveira Santana (Graduando do Curso de Farm\u00e1cia)<\/p>\n

Maria Fernanda Martins Durval (Mestranda)<\/p>\n

Miriam Pereira da Concei\u00e7\u00e3o Euz\u00e9bio (Graduanda do Curso de Farm\u00e1cia)<\/p>\n

Priscila Soares Ferreira (Mestranda)<\/p>\n

Rafaela Montiel Rodrigues (Graduanda do Curso de Farm\u00e1cia)<\/p>\n

Richard Chagas da Luz (Graduanda do curso de Farm\u00e1cia)<\/p>\n

Samantha da Silva Souza Silva (Graduanda do Curso de Farm\u00e1cia)<\/p>\n

Tamires Pereira (Graduanda do Curso de Farm\u00e1cia)<\/p>\n

 <\/p>\n

Produ\u00e7\u00e3o \u00faltimos 5 anos:<\/p>\n

LAUREANO-MELO R; SOUZA JS; DA CONCEI\u00c7\u00c3O RR; ALBUQUERQUE JML; RODRIGUES NC; MARINHO BG<\/strong>; OLIVARES EL; GIANNOCCO G; C\u00d4RTES WS<\/strong>. Prenatal thyroxine treatment promotes anxiolysis in male Swiss mice offspring. HORMONES AND BEHAVIOR, v. 108, p. 10-19, 2019.<\/p>\n

SANTOS GCM; SANCHES MNG; CHAVES DSA; DE CARVALHO MG; BRAZ FILHO R; MARINHO BG.<\/strong> Participation of cytokines, opioid, and serotoninergic systems on antinociceptive and anti-inflammatory activities of Simira grazielae<\/em> Peixoto (Rubiaceae). PHARMACOGNOSY RESEARCH, v. 11, p. 51, 2019.<\/p>\n

LAUREANO-MELO R; CALDEIRA RF; GUERRA AF; CONCEI\u00c7\u00c3O RR; SOUZA JS; GIANNOCCO G; MARINHO BG<\/strong>; LUCHESE RH; C\u00d4RTES WS<\/strong>. Maternal supplementation with Lactobacillus paracasei DTA 83 alters emotional behavior in Swiss mice offspring. PHARMANUTRITION, v. 8, p. 100148, 2019.<\/p>\n

OLIVEIRA PA; FIDELIS QC; FERNANDES TFC; SOUZA MC; COUTINHO DM; PRUD\u00caNCIO ER; CASTRO RN; RIGER CJ; DE CARVALHO MG; MARINHO BG<\/strong>. Evaluation In Vivo and In Vitro of the Antioxidant, Antinociceptive, and Anti-Inflammatory Activities of Biflavonoids From Ouratea hexasperma<\/em> and ferruginea<\/em>. NATURAL PRODUCT COMMUNICATIONS, v. 14, p. 1934578X1985680-1, 2019.<\/p>\n

KANASHIRO A; LUCENA TO; SCHNEIDER AH; ALVES HR; BASSI GS; DUTRA SGV; CUNHA FQ; ULLOA L; MALVAR DC<\/strong>. Regulation of murine arthritis by systemic, spinal, and intra-articular adrenoceptors. PHARMACOLOGICAL REPORTS, 2019.<\/p>\n

SCHNEIDER AH; KANASHIRO A; DUTRA SGV; SOUZA RN; VERAS FP; CUNHA FQ; ULLOA L; MECAWI AS; REIS LC; MALVAR DC<\/strong>. Estradiol replacement therapy regulates innate immune response in ovariectomized arthritic mice. INTERNATIONAL IMMUNOPHARMACOLOGY, v.72, p.504 – 510, 2019.<\/p>\n

MOREIRA AS; ESTATO V; MALVAR DC<\/strong>; SANCHES GS; GOMES F; TIBIRI\u00c7A E; DANIEL-RIBEIRO CT; CARVALHO LJM. L-arginine supplementation and thromboxane synthase inhibition increases cerebral blood flow in experimental cerebral malaria. SCIENTIFIC REPORTS, v.9, p.13621 – , 2019.<\/p>\n

OLIVEIRA PA; DE ALMEIDA TB; DE OLIVEIRA RG; GON\u00c7ALVES GM; DE OLIVEIRA JM; DOS SANTOS BBA; LAUREANO-MELO R; C\u00d4RTES WS<\/strong>; FRAN\u00c7A TN; VASCONCELLOS MLAA; MARINHO BG<\/strong>. Evaluation of the antinociceptive and anti-inflammatory activities of piperic acid: Involvement of the cholinergic and vanilloid systems. EUROPEAN JOURNAL OF PHARMACOLOGY, v. 834, p. 54-64, 2018.<\/p>\n

SANTOS-JUNIOR NN; CATAL\u00c3O CH; COSTA LH; ROSSIGNOLI BB; DOS-SANTOS RC; MALVAR DC<\/strong>; MECAWI AS; ROCHA MJ. Alterations in hypothalamic synaptophysin and death markers may be associated with vasopressin impairment in sepsis survivor rats. JOURNAL OF NEUROENDOCRINOLOGY, v.30, p.e12604, 2018.<\/p>\n

LIMA IC; CASTRO RN; CHAVES DSA; FERREIRA RT; CARVALHO MF; MALVAR DC<\/strong>; VANDERLINDE FA. The folk medicine as tool for discovery of new anti-inflammatory drugs: the example of Spermacoce verticillata<\/em>. ACTA HORTICULTURAE, v.1, p.67 – 74, 2018.<\/p>\n

SOUSA S; ROCHA J; KEESEN T; SILVA E; DE ASSIS P; DE OLIVEIRA J; CAPIM S; XAVIER F; MARINHO BG<\/strong>; SILVA F; LIMA’JUNIOR C; VASCONCELLOS M. Synthesis of 16 New Hybrids from Tetrahydropyrans Derivatives and Morita-Baylis-Hillman Adducts: In vitro Screening against Leishmania donovani. MOLECULES (BASEL. ONLINE), v. 22, p. 207-221, 2017.<\/p>\n

CARNEIRO LU; SILVA IG; SOUZA MEA; C\u00d4RTES WS<\/strong>; DE CARVALHO MG; MARINHO BG<\/strong>. Antinociceptive and anti-inflammatory activities of leaf extracts from Annona tomentosa<\/em>E.Fr. JOURNAL OF INTEGRATIVE MEDICINE, v. 15, p. 379-387, 2017.<\/p>\n

ALMAN\u00c7A CCJ; MARINHO BG<\/strong>. Activity of the hydroethanolic extract of Buddleja brasiliensis<\/em> Jacq ex. Spreng Fam. on acute pain induced in mice. INTERNATIONAL JOURNAL OF PAIN AND RELIEF, v. 01, p. 01-07, 2017.<\/p>\n

MENDONCA DA; OLIVEIRA PA; KAPLAN MAC; DE CARVALHO MG; SUZART LR; MARINHO BG<\/strong>. The 2\u03b1-3\u03b2-6\u03b2-23-tetrahydro-olean-12-en-28-oic acid from the leaves of chrysobalanus icaco<\/em> attenuates the inflammatory hypernociception in mice. INTERNATIONAL JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, v. 9, p. 94-100, 2017.<\/p>\n

BASSI GS; MALVAR DC<\/strong>; CUNHA TM; CUNHA FQ; KANASHIRO, A. Spinal GABA-B receptor modulates neutrophil recruitment to the knee joint in zymosan-induced arthritis. Naunyn-Schmiedeberg’s Archives of Pharmacology<\/em>, v.389, p.851 – 861, 2016.<\/p>\n

LAUREANO-MELO R; DA SILVEIRA ALB; SEARA FAC; DA CONCEI\u00c7\u00c3O RR; DA SILVA-ALMEIDA C; MARINHO BG<\/strong>; DA ROCHA FF; REIS LC; C\u00d4RTES WS<\/strong>. Behavioral profile assessment in offspring of Swiss mice treated during pregnancy and lactation with caffeine. METABOLIC BRAIN DISEASE, v. 1, p. 1, 2016.<\/p>\n

GON\u00c7ALVES GM; CAPIM SL; VASCONCELLOS ML; MARINHO BG<\/strong>. Antihyperalgesic effect of [(\u00b1)-(2,4,6-cis)-4-chloro-6-(naphthalen-1-yl)-tetrahydro-2H-pyran-2-yl]methanol: participation of the NO\/cGMP\/KATP pathway and \u03ba-opioid receptor. BEHAVIOURAL PHARMACOLOGY, v. 27, p. 1, 2016.<\/p>\n

KANASHIRO A; FIGUEIREDO MJ; MALVAR DC<\/strong>; SOUZA GEP. Cytokines, but not corticotropin-releasing factor and endothelin-1, participate centrally in the febrile response in zymosan-induced arthritis in rats. Brain Research, p.12 – 19, 2015.<\/p>\n

VIEIRA AA; MARINHO BG<\/strong>; DE SOUZA LG; FERNANDES PD; FIGUEROA-VILLAR JD. Design, synthesis and in vivo evaluation of sodium 2-benzyl-chloromalonates as new central nervous system depressants. MED CHEM COMM, v. 6, p. 1427-1437, 2015.<\/p>\n

DOS SANTOS G; FERNANDES R; BARROS T; ABREU H; SUZART L; DE CARVALHO MG; BRAZ FILHO R; MARINHO BG<\/strong>. Antinociceptive and Anti-inflammatory Activities of the Methanolic Extract from the Stem Bark of Lophanthera lactescens<\/em>. PLANTA MEDICA, v. 81, p. 1688-1696, 2015.<\/p>\n

MALVAR DC<\/strong>; FERREIRA RT; DE CASTRO RA; DE CASTRO LL; FREITAS ACC; COSTA EA; FLORENTINO IF; MAFRA, JCM; DE SOUZA GEP; VANDERLINDE, FA. Antinociceptive, anti-inflammatory and antipyretic effects of 1.5-diphenyl-1H-Pyrazole-3-carbohydrazide, a new heterocyclic pyrazole derivative. LIFE SCIENCES (1973), v.95, p.81 – 88, 2014.<\/p>\n

MALVAR DC<\/strong>; AGUIAR FA; VAZ ALL; ASSIS DCR; DE MELO MCC; JABOR VAP; KALAPOTHAKIS E; FERREIRA SH; CLOSOSKI GC; SOUZA GEP. Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2-dependent and -independent fever while 4-AA only blocks PGE2-dependent fever. BRITISH JOURNAL OF PHARMACOLOGY, v.171, p.3666 – 3679, 2014.<\/p>\n

FERREIRA RT; COUTINHO MAS; MALVAR DC<\/strong>; COSTA EA; FLORENTINO IF; COSTA SS; VANDERLINDE FA. Mechanisms Underlying the Antinociceptive, Antiedematogenic, and Anti-Inflammatory Activity of the Main Flavonoid from Kalanchoe pinnata<\/em>. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (Print), v.2014, p.1 – 8, 2014.<\/p>\n

MALVAR DC<\/strong>; AGUIAR FA; VAZ ALL; ASSIS DCR; MELO MCC; JABOR VAP; KALAPOTHAKIS E; FERREIRA SH; CLOSOSKI GC; SOUZA GE. The dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2-dependent and-independent fever while 4-AA only blocks PGE2-dependent fever. BRITISH JOURNAL OF PHARMACOLOGY, v.171, p.3666 – 3679, 2014.<\/p>\n

DOS SANTOS G; GOMES G; GON\u00c7ALVES G; DE SOUSA L; SANTIAGO G; DE CARVALHO MG; MARINHO, BG<\/strong>. Essential Oil from Myrcia ovata<\/em>: Chemical Composition, Antinociceptive and Anti-Inflammatory Properties in Mice. PLANTA MEDICA, v. 80, p. 1588-1596, 2014.<\/p>\n","protected":false},"excerpt":{"rendered":"

Descri\u00e7\u00e3o do Laborat\u00f3rio de Farmacologia da inflama\u00e7\u00e3o e nocicep\u00e7\u00e3o   O Laborat\u00f3rio de Farmacologia da inflama\u00e7\u00e3o e nocicep\u00e7\u00e3o \u00e9 coordenado … leia mais <\/i><\/span><\/a><\/p>\n","protected":false},"author":57,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-373","page","type-page","status-publish","hentry"],"yoast_head":"\nLaborat\u00f3rio de farmacologia da inflama\u00e7\u00e3o e da nocicep\u00e7\u00e3o - Programa de P\u00f3s-Gradua\u00e7\u00e3o Multic\u00eantrico em Ci\u00eancias Fisiol\u00f3gicas<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cursos.ufrrj.br\/posgraduacao\/pmpgcf\/laboratorio-de-farmacologia-da-inflamacao-e-nocicepcao\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Laborat\u00f3rio de farmacologia da inflama\u00e7\u00e3o e da nocicep\u00e7\u00e3o - 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